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Article

Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros

26 Apr 2006

Abstract excerpt

Megalin/LRP2 is an endocytic receptor in the proximal tubules of the mammalian kidney that plays a central role in the clearance of metabolites from the glomerular filtrate. To establish a genetic model system for elucidation of molecular components of this retrieval pathway, we characterized orthologous transport processes in the zebrafish. We show that expression of megalin/LRP2 and its co-receptor cubilin is...

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PMID: 16638803
DOI: 10.1242/jcs.02954

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