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Article

Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption.

Blood - 15 Nov 1999

Xu D, Kozyraki R, Newman T C, Fyfe J C

Abstract excerpt

Cubilin is a high molecular weight multiligand receptor that mediates intestinal absorption of intrinsic factor-cobalamin and selective protein reabsorption in renal tubules. The genetic basis of selective intestinal cobalamin malabsorption with proteinuria was investigated in a canine model closely resembling human Imerslund-Gräsbeck syndrome caused by cubilin mutations. Canine CUBN cDNA was cloned and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10552972

Genes

CUBN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption.PMID 10552972Read ↗

Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo.Semantic proximity Read ↗

Selective intestinal cobalamin malabsorption with proteinuria (Imerslund-Gräsbeck syndrome) in juvenile Beagles.Semantic proximity Read ↗

A Frameshift Mutation in the Cubilin Gene (CUBN) in Border Collies with Imerslund-Gräsbeck Syndrome (Selective Cobalamin Malabsorption)Semantic proximity Read ↗

The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless.Semantic proximity Read ↗

Detailed investigations of proximal tubular function in Imerslund-Gräsbeck syndromeSemantic proximity Read ↗

Novel CUBN Mutation in a Young Child With Megaloblastic Anemia.Semantic proximity Read ↗

Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1.Semantic proximity Read ↗

A frameshift mutation in the cubilin gene (<i><scp>CUBN</scp></i>) in <scp>B</scp>eagles with <scp>I</scp>merslund–<scp>G</scp>räsbeck syndrome (selective cobalamin malabsorption)Semantic proximity Read ↗

Canine Imerslund-Gräsbeck syndrome maps to a region orthologous to HSA14q.Semantic proximity Read ↗

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Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns.Semantic proximity Read ↗

AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2.Semantic proximity Read ↗

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