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Article

Heterozygous knockout of the Bmi-1 gene causes an early onset of phenotypes associated with brain aging.

Age (Dordrecht, Netherlands) - 1 Feb 2014

Gu Minxia, Shen Lihua, Bai Lei, Gao Junying, Marshall Charles, Wu Ting, Ding Jiong, Miao Dengshun, Xiao Ming

Abstract excerpt

Previous studies reported that the polycomb group gene Bmi-1 is downregulated in the aging brain. The aim of this study was to investigate whether decreased Bmi-1 expression accelerates brain aging by analyzing the brain phenotype of adult Bmi-1 heterozygous knockout (Bmi-1(+/-)) mice. An 8-month-old Bmi-1(+/-) brains demonstrated mild oxidative stress, revealed by significant increases in hydroxy radical and...

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Identifiers

PMID: 23771506
DOI: 10.1007/s11357-013-9552-9
PMCID: PMC3889899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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