Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice

27 Feb 2011

Abstract excerpt

The decline in cognitive robustness with aging can be attributed to complex genetic pathways involving many cellular dysfunctions, cumulative over time, precipitating in frailty and loss of wellness in the elderly brain. The size and health of the neuronal cell population determines cognitive robustness in mammals. A transgenic mouse model over-expressing Bcl-2 has been shown to rescue neurons from naturally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Autophagy in Disease and Therapy
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21415464
DOI: 10.18632/aging.100276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted micePMID 21415464Read ↗

Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain agingSemantic proximity Read ↗

Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.Semantic proximity Read ↗

Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injurySemantic proximity Read ↗

Temporal linkage between the phenotypic and genomic responses to caloric restriction.Semantic proximity Read ↗

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4–CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMASemantic proximity Read ↗

Maternal folic acid deficiency stimulates neural cell apoptosis via miR‐34a associated with Bcl‐2 in the rat foetal brainSemantic proximity Read ↗

AlphaMUPA mice: a transgenic model for longevity induced by caloric restriction.Semantic proximity Read ↗

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim.Semantic proximity Read ↗

Differential Expression of Rat Brain Bcl-2 Family Proteins in Development and AgingSemantic proximity Read ↗

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Semantic proximity Read ↗

The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's diseaseSemantic proximity Read ↗

The pro-apoptotic protein Bmf co-operates with Bim and Puma in neuron death induced by β-amyloid or NGF deprivationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.