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Article

Barrett's esophagus in the patients with familial adenomatous polyposis.

Familial cancer - 1 Jun 2014

Gatalica Zoran, Chen Mingkui, Snyder Carrie, Mittal Sumeet, Lynch Henry T

Abstract excerpt

Familial adenomatous polyposis (FAP) is caused by germ line mutations in the APC gene. Barrett's esophagus (BE) and Barrett's adenocarcinoma are intestinal type lesions of the esophagus characterized by an early loss of heterozygosity at the APC locus. We hypothesized that patients with FAP are at risk for the early development of BE due to the inherited mutations in the APC gene (haploinsufficiency). Upper...

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Source

Identifiers

PMID: 23771323
DOI: 10.1007/s10689-013-9638-7

Genes

FAP
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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