Article
Colon cancer prevention by detection of APC gene mutation in a family with attenuated familial adenomatous polyposis.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012
Poovorawan Kittiyod, Suksawatamnuay Sirinporn, Sahakitrungruang Chucheep, Treeprasertsuk Sombat, Wisedopas Naruemon, Komolmit Piyawat, Poovorawan Yong
Abstract excerpt
BACKGROUND: Genetic mutation is a significant factor in colon CA pathogenesis. Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary disease characterized by multiple colorectal adenomatous polyps affecting a number of cases in the family. This report focuses on a family with attenuated familial adenomatous polyposis (AFAP) with exon 4 mutation, c.481C>T p.Q161X of the APC gene. METHODS: We...
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