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Article

Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization

15 Jun 2013

Abstract excerpt

The four serotypes of dengue virus (DENV-1 to -4) cause the most important arthropod-borne viral disease of humans. DENV non-structural protein 5 (NS5) contains enzymatic activities required for capping and replication of the viral RNA genome that occurs in the host cytoplasm. However, previous studies have shown that DENV-2 NS5 accumulates in the nucleus during infection. In this study, we examined the nuclear...

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PMID: 23770669
DOI: 10.1074/jbc.m113.481382

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