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Nucleocytoplasmic shuttling of the West Nile virus RNA ‐dependent RNA polymerase NS5 is critical to infection

26 Mar 2018

Abstract excerpt

West Nile virus (WNV) is a single-stranded, positive sense RNA virus of the family Flaviviridae and is a significant pathogen of global medical importance. Flavivirus replication is known to be exclusively cytoplasmic, but we show here for the first time that access to the nucleus of the WNV strain Kunjin (WNVKUN) RNA-dependent RNA polymerase (protein NS5) is central to WNVKUN virus production. We show that...

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PMID: 29582535
DOI: 10.1111/cmi.12848

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