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Article

Examining the stability of genetic risk effect as evidence accumulates in the context of meta-analysis.

Computers in biology and medicine - 1 Sept 2013

Zintzaras Elias

Abstract excerpt

The recursive cumulative meta-analysis (RCM) of genetic association studies explores the relative change of the cumulative risk effect (e.g. OR) in time, indicating the stability of risk effect as evidence accumulates. However, the stability in risk effect is currently evaluated empirically with a graphical approach. A Monte Carlo permutation test for examining the instability in RCM is proposed. The statistic...

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PMID: 23768991
DOI: 10.1016/j.compbiomed.2013.04.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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