Article
Accurately identifying low-allelic fraction variants in single samples with next-generation sequencing: applications in tumor subclone resolution.
Human mutation - 1 Oct 2013
Stead Lucy F, Sutton Kate M, Taylor Graham R, Quirke Philip, Rabbitts Pamela
Abstract excerpt
Current methods for resolving genetically distinct subclones in tumor samples require somatic mutations to be clustered by allelic frequencies, which are determined by applying a variant calling program to next-generation sequencing data. Such programs were developed to accurately distinguish true polymorphisms and somatic mutations from the artifactual nonreference alleles introduced during library preparation...
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