Article
Detecting very low allele fraction variants using targeted DNA sequencing and a novel molecular barcode-aware variant caller.
BMC genomics - 3 Jan 2017
Xu Chang, Nezami Ranjbar Mohammad R, Wu Zhong, DiCarlo John, Wang Yexun
Abstract excerpt
BACKGROUND: Detection of DNA mutations at very low allele fractions with high accuracy will significantly improve the effectiveness of precision medicine for cancer patients. To achieve this goal through next generation sequencing, researchers need a detection method that 1) captures rare mutation-containing DNA fragments efficiently in the mix of abundant wild-type DNA; 2) sequences the DNA library extensively...
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