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Article

The impact of pre-existing memory on differentiation of newly recruited naive CD8 T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2011

Martin Matthew D, Wirth Thomas C, Lauer Peter, Harty John T, Badovinac Vladimir P

Abstract excerpt

One goal of immunization is to generate memory CD8 T cells of sufficient quality and quantity to confer protection against infection. It has been shown that memory CD8 T cell differentiation in vivo is controlled, at least in part, by the amount and duration of infection, Ag, and inflammatory cytokines present early after the initiation of the response. In this study, we used models of anti-vectorial immunity to...

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Identifiers

PMID: 21832161
DOI: 10.4049/jimmunol.1100698
PMCID: PMC3169750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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