Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records.

doi:10.1371/journal.pone.0063481

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Article

Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records.

PloS one - 1 Jan 2013

McDavid Andrew, Crane Paul K, Newton Katherine M, Crosslin David R, McCormick Wayne, Weston Noah, Ehrlich Kelly, Hart Eugene, Harrison Robert, Kukull Walter A, Rottscheit Carla, Peissig Peggy, Stefanski Elisha, McCarty Catherine A, Zuvich Rebecca Lynn, Ritchie Marylyn D, Haines Jonathan L, Denny Joshua C, Schellenberg Gerard D, de Andrade Mariza, Kullo Iftikhar, Li Rongling, Mirel Daniel, Crenshaw Andrew, Bowen James D, Li Ge, Tsuang Debby, McCurry Susan, Teri Linda, Larson Eric B, Jarvik Gail P, Carlson Chris S

Abstract excerpt

The feasibility of using imperfectly phenotyped "silver standard" samples identified from electronic medical record diagnoses is considered in genetic association studies when these samples might be combined with an existing set of samples phenotyped with a gold standard technique. An analytic ex...

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PMID: 23762230
DOI: 10.1371/journal.pone.0063481
PMCID: PMC3677889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23762230-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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