Article
How to use an article about genetic association: A: Background concepts.
JAMA - 7 Jan 2009
Attia John, Ioannidis John P A, Thakkinstian Ammarin, McEvoy Mark, Scott Rodney J, Minelli Cosetta, Thompson John, Infante-Rivard Claire, Guyatt Gordon
Abstract excerpt
This is the first in a series of 3 articles serving as an introduction to clinicians wishing to read and critically appraise genetic association studies. We summarize the key concepts in genetics that clinicians must understand to review these studies, including the structure of DNA, transcription and translation, patterns of inheritance, Hardy-Weinberg equilibrium, and linkage disequilibrium. We review the types...
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