Article
Renal phenotype of low kallikrein rats.
Kidney international - 1 Jun 2001
Madeddu P, Vio C P, Straino S, Salis M B, Milia A F, Emanueli C
Abstract excerpt
BACKGROUND: Renal kallikrein has been linked with inheritance of arterial hypertension and with sensitivity to drug nephrotoxicity. Identification of a cause--effect relationship between low kallikrein and intermediate phenotypes has been hampered by the lack of adequate animal models. METHODS: Kallikrein was measured in tissues obtained from rats inbred for low urinary kallikrein excretion (LKR) and wild-type...
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