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Article

Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer.

British journal of cancer - 25 Jun 2013

Barnes D R, Barrowdale D, Beesley J, Chen X, James P A, Hopper J L, Goldgar D, Chenevix-Trench G, Antoniou A C, Mitchell G

Abstract excerpt

BACKGROUND: Pedigrees with multiple genotyped family members have been underutilised in breast cancer (BC) genetic-association studies. We developed a pedigree-based analytical framework to characterise single-nucleotide polymorphism (SNP) associations with BC risk using data from 736 BC families ascertained through multiple affected individuals. On average, eight family members had been genotyped for 24 SNPs...

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Source

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Identifiers

PMID: 23756864
DOI: 10.1038/bjc.2013.277
PMCID: PMC3694253

Genes

LSP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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