Article
Gender-specific profiling in SCN1A polymorphisms and time-to-recurrence in patients with stage II/III colorectal cancer treated with adjuvant 5-fluoruracil chemotherapy.
The pharmacogenomics journal - 1 Apr 2014
Benhaim L, Gerger A, Bohanes P, Paez D, Wakatsuki T, Yang D, Labonte M J, Ning Y, El-Khoueiry R, Loupakis F, Zhang W, Laurent-Puig P, Lenz H J
Abstract excerpt
This study was designed to analyze the gender-related association between SCN1A polymorphisms (voltage-gated sodium channels; α-subunit) and time-to-recurrence (TTR) in patients with colorectal cancer (CRC) treated with 5-fluoruracil (5-FU)-based adjuvant chemotherapy. We enrolled from a prospective database patients with stage II and III CRC treated with adjuvant 5-FU-based chemotherapy. Genotypes for SCN1A...
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