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Article

Influence of FCGRT gene polymorphisms on pharmacokinetics of therapeutic antibodies

25 Apr 2013

Abstract excerpt

The neonatal Fc receptor (FcRn) encoded by FCGRT is known to be involved in the pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs). Variability in the expression of FCGRT gene and consequently in the FcRn protein level could explain differences in PK observed between patients treated with mAbs. We studied whether the previously described variable number tandem repeat (VNTR) or copy number variation...

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PMID: 23751752
DOI: 10.4161/mabs.24815

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