Article
Complement activation in diseases presenting with thrombotic microangiopathy.
European journal of internal medicine - 1 Sept 2013
Meri Seppo
Abstract excerpt
The complement system contains a great deal of biological "energy". This is demonstrated by the atypical hemolytic uremic syndrome (aHUS), which is a thrombotic microangiopathy (TMA) characterized by endothelial and blood cell damage and thrombotic vascular occlusions. Kidneys and often also other organs (brain, lungs and gastrointestinal tract) are affected. A principal pathophysiological feature in aHUS is a...
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