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Article

Analysis of the use of codon pairs in the HE gene of the ISA virus shows a correlation between bias in HPR codon-pair use and mortality rates caused by the virus.

Virology journal - 6 Jun 2013

Tello Mario, Saavedra José Miguel, Spencer Eugenio

Abstract excerpt

BACKGROUND: Segment 6 of the ISA virus codes for hemoagglutinin-esterase (HE). This segment is highly variable, with more than 26 variants identified. The major variation is observed in what is called the high polymorphism region (HPR). The role of the different HPR zones in the viral cycle or evolution remains unknown. However viruses that present the HPR0 are avirulent, while viruses with important deletions in...

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Identifiers

PMID: 23742749
DOI: 10.1186/1743-422X-10-180
PMCID: PMC3684539

Genes

HPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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