Article
Pandemic influenza A virus codon usage revisited: biases, adaptation and implications for vaccine strain development.
Virology journal - 8 Nov 2012
Goñi Natalia, Iriarte Andrés, Comas Victoria, Soñora Martín, Moreno Pilar, Moratorio Gonzalo, Musto Héctor, Cristina Juan
Abstract excerpt
BACKGROUND: Influenza A virus (IAV) is a member of the family Orthomyxoviridae and contains eight segments of a single-stranded RNA genome with negative polarity. The first influenza pandemic of this century was declared in April of 2009, with the emergence of a novel H1N1 IAV strain (H1N1pdm) in Mexico and USA. Understanding the extent and causes of biases in codon usage is essential to the understanding of...
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