Article
Rapid sequence modification in the highly polymorphic region (HPR) of the hemagglutinin gene of the infectious salmon anaemia virus (ISAV) suggests intra-segmental template switching recombination.
Journal of fish diseases - 1 Dec 2020
Cárdenas Matías, Galleguillos Claudia, Acevedo Karina, Ananias Catarina, Alarcón Javiera, Michelson Sofía, Toledo Jorge, Montoya Margarita, Meneses Claudio, Castro-Nallar Eduardo, Vásquez-Martínez Yesseny, Cortez-San Martin Marcelo
Abstract excerpt
The ISAV has a genome composed of eight segments of (-)ssRNA, segment 6 codes for the hemagglutinin-esterase protein, and has the most variable region of the genome, the highly polymorphic region (HPR), which is unique among orthomyxoviruses. The HPR has been associated with virulence, infectivity and pathogenicity. The full length of the HPR is called HPR0 and the strain with this HPR is avirulent, in contrast...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.