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Article

Keratin 17 null mice exhibit age- and strain-dependent alopecia.

Genes & development - 1 Jun 2002

McGowan Kevin M, Tong Xuemei, Colucci-Guyon Emma, Langa Francina, Babinet Charles, Coulombe Pierre A

Abstract excerpt

Onset of type I keratin 17 (K17) synthesis marks the adoption of an appendageal fate within embryonic ectoderm, and its expression persists in specific cell types within mature hair, glands, and nail. We report that K17 null mice develop severe alopecia during the first week postbirth, correlating with hair fragility, alterations in follicular histology, and apoptosis in matrix cells. These alterations are...

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Source

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Identifiers

PMID: 12050118
DOI: 10.1101/gad.979502
PMCID: PMC186322

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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