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Article

Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis

4 Jun 2013

Abstract excerpt

Disappearance of TAR-DNA-binding protein 43 kDa (TDP-43) from the nucleus contributes to the pathogenesis of amyotrophic lateral sclerosis (ALS), but the nuclear function of TDP-43 is not yet fully understood. TDP-43 associates with nuclear bodies including Gemini of coiled bodies (GEMs). GEMs contribute to the biogenesis of uridine-rich small nuclear RNA (U snRNA), a component of splicing machinery. The number...

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PMID: 23740936
DOI: 10.1093/hmg/ddt262

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