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<i>C9ORF72</i> dipeptide repeat proteins disrupt formation of GEM bodies and induce aberrant accumulation of survival of motor neuron protein

2021-03-25

Abstract excerpt

A GGGGCC repeat expansion in the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. In the neurons of ALS patients, dipeptide repeat proteins (DPRs) are produced from repeat-containing RNAs by an unconventional form of translation, and some of these proteins, especially those containing poly(glycine-arginine) and poly(proline-arginine), are to...

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Literature Corpus work
fb3b0115-7955-53db-8916-c85ac1f17348
DOI
10.1101/2021.03.24.436890
Open publication

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<i>C9ORF72</i> dipeptide repeat proteins disrupt formation of GEM bodies and induce aberrant accumulation of survival of motor neuron proteinDOI 10.1101/2021.03.24.436890
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