Article
Functional properties of five Dictyostelium discoideum P2X receptors.
The Journal of biological chemistry - 19 Jul 2013
Baines Abigail, Parkinson Katie, Sim Joan A, Bragg Laricia, Thompson Christopher R L, North R Alan
Abstract excerpt
The Dictyostelium discoideum genome encodes five proteins that share weak sequence similarity with vertebrate P2X receptors. Unlike vertebrate P2X receptors, these proteins are not expressed on the surface of cells, but populate the tubules and bladders of the contractile vacuole. In this study, we expressed humanized cDNAs of P2XA, P2XB, P2XC, P2XD, and P2XE in human embryonic kidney cells and altered the ionic...
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