Article
Validation and quantification of genetic determinants of lipoprotein-a levels and predictive value for angiographic coronary artery disease.
The American journal of cardiology - 15 Sept 2013
Anderson Jeffrey L, Knight Stacey, May Heidi T, Horne Benjamin D, Bair Tami L, Huntinghouse John A, Rollo Jeffrey S, Muhlestein Joseph B, Carlquist John F
Abstract excerpt
Lipoprotein(a) (Lp[a]) has gained attention as a heritable coronary artery disease (CAD) risk factor and therapeutic target. Two genetic variants in the LPA gene have been reported to influence Lp(a) levels and increase CAD risk. The aim of this study was to prospectively test these variants for their associations with Lp(a) and CAD risk. Participants (n = 1,400) in the Intermountain Heart Collaborative Study...
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