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TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis

21 Dec 2024

Abstract excerpt

The TGFβ signaling pathway is known for its pleiotropic functions in a plethora of biological processes. In melanoma, TGFβ signaling promotes invasiveness and metastasis formation. However, its involvement in the response to therapy is controversial. While several studies have linked TGFβ signaling to elevated resistance to targeted therapy in melanoma, separate findings have indicated a favorable treatment...

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PMID: 39709491
DOI: 10.1038/s41419-024-07305-1

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