Article
Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk.
Circulation. Cardiovascular genetics - 1 Aug 2013
Fan Meng, Dandona Sonny, McPherson Ruth, Allayee Hooman, Hazen Stanley L, Wells George A, Roberts Robert, Stewart Alexandre F R
Abstract excerpt
BACKGROUND: Variants at the 9p21 locus associate with the risk of coronary artery disease (CAD) or myocardial infarction (MI). However, atherosclerotic plaque deposition is distinct from MI (plaque rupture and thrombosis), and recent studies showed no association between these variants and MI in patients with preexisting CAD. We performed haplotype analysis at the 9p21 locus to test whether haplotypes at distinct...
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