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Article

Substrate ambiguous enzymes within the Escherichia coli proteome offer different evolutionary solutions to the same problem.

Molecular biology and evolution - 1 Sept 2013

Yip Sylvia Hsu-Chen, Matsumura Ichiro

Abstract excerpt

Many enzymes exhibit some catalytic promiscuity or substrate ambiguity. These weak activities do not affect the fitness of the organism under ordinary circumstances, but can serve as potential evolutionary precursors of new catalytic functions. We wondered whether different proteins with the same...

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Identifiers

PMID: 23728795
DOI: 10.1093/molbev/mst105
PMCID: PMC3842161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23728795-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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