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Additive Promotion of Viral Internal Ribosome Entry Site-Mediated Translation by Far Upstream Element-Binding Protein 1 and an Enterovirus 71-Induced Cleavage Product

25 Oct 2016

Abstract excerpt

The 5' untranslated region (5' UTR) of the enterovirus 71 (EV71) RNA genome contains an internal ribosome entry site (IRES) that is indispensable for viral protein translation. Due to the limited coding capacity of their RNA genomes, EV71 and other picornaviruses typically recruit host factors, known as IRES trans-acting factors (ITAFs), to mediate IRES-dependent translation. Here, we show that EV71 viral...

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RNA and protein synthesis mechanisms
RNA regulation and disease
Viral Infections and Immunology Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27780225
DOI: 10.1371/journal.ppat.1005959

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