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Article

DEPDC5 as a potential therapeutic target for epilepsy.

Expert opinion on therapeutic targets - 1 Jun 2017

Myers Kenneth A, Scheffer Ingrid E

Abstract excerpt

INTRODUCTION: Dishevelled, Egl-10 and Pleckstrin (DEP) domain-containing protein 5 (DEPDC5) is a protein subunit of the GTPase-activating proteins towards Rags 1 (GATOR1) complex. GATOR1 is a recently identified modulator of mechanistic target of rapamycin (mTOR) activity. mTOR is a key regulator of cell proliferation and metabolism; disruption of the mTOR pathway is implicated in focal epilepsy, both acquired...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28406046
DOI: 10.1080/14728222.2017.1316715

Genes

DEPDC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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DEPDC5 as a potential therapeutic target for epilepsy.PMID 28406046Read ↗

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Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy.Semantic proximity Read ↗

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mTOR signaling in epilepsy: insights from malformations of cortical development.Semantic proximity Read ↗

Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy.Semantic proximity Read ↗

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