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Article

Radioresistant Cancer Cells Can Be Conditioned to Enter Senescence by mTOR Inhibition

31 May 2013

Abstract excerpt

Autophagy is frequently activated in radioresistant cancer cells where it provides a cell survival strategy. The mTOR inhibitor rapamycin activates autophagy but paradoxically it also enhances radiosensitivity. In this study, we investigated the mechanisms of these opposing actions in radiation-resistant glioma or parotid carcinoma cells. Radiation treatment transiently enhanced autophagic flux for a period of 72...

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Share to Autophagy in Disease and Therapy
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PMID: 23722550
DOI: 10.1158/0008-5472.can-12-3516

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