Rapamycin‐induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition

Abstract excerpt

BACKGROUND: Autophagy has been reported to increase in cancer cells after radiation. However, it remains unknown whether increased autophagy as a result of radiation affects DNA damage repair and sensitizes cancer cells. In this study, the radiosensitization effect of rapamycin, a mammalian target of rapamycin inhibitor that induces autophagy, on human lung adenocarcinoma A549 cells was investigated. METHODS:...

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