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Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma

19 Oct 2023

Abstract excerpt

BACKGROUND: Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA complex, are potential therapeutic targets for reversing NPC radioresistance. Nevertheless, the role of RPA in autophagy is not adequately understood. This investigation was performed to reveal the cytotoxic mechanism of a pharmacologic RPA inhibitor (RPAi) in NPC...

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PMID: 37858134
DOI: 10.1186/s12967-023-04574-w

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