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notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish.

Disease models & mechanisms - 1 Sept 2013

Zaucker Andreas, Mercurio Sara, Sternheim Nitzan, Talbot William S, Marlow Florence L

Abstract excerpt

Mutations in the human NOTCH3 gene cause CADASIL syndrome (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). CADASIL is an inherited small vessel disease characterized by diverse clinical manifestations including vasculopathy, neurodegeneration and dementia. Here we report two mutations in the zebrafish notch3 gene, one identified in a previous screen for mutations with...

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Blood Vessels
Hemorrhage
Myelin Basic Protein
Neurogenesis
Oligodendroglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Notch3

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Open in PubMed Open full text

Identifiers

PMID: 23720232
DOI: 10.1242/dmm.012005
PMCID: PMC3759344

Genes

NOTCH3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish.PMID 23720232Read ↗

Progress to Clarify How NOTCH3 Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease.Semantic proximity Read ↗

Pathogenesis of CADASIL: transgenic and knock-out mice to probe function and dysfunction of the mutated gene, Notch3, in the cerebrovasculature.Semantic proximity Read ↗

Age-dependent vascular and neurological characteristics of CADASIL are recapitulated in Notch3 mutant zebrafish, implicating a role for type IV collagen in disease progression.Semantic proximity Read ↗

NOTCH3 Mutations in CADASIL: a multicellular perspective on neurodegeneration.Semantic proximity Read ↗

Homozygous NOTCH3 null mutation and impaired NOTCH3 signaling in recessive early‐onset arteriopathy and cavitating leukoencephalopathySemantic proximity Read ↗

NOTCH3 R545C mutation drives vascular-neuronal dysfunction and cognitive impairment in CADASIL pathogenesis.Semantic proximity Read ↗

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients.Semantic proximity Read ↗

CADASILSemantic proximity Read ↗

Notch3 in Development, Health and Disease.Semantic proximity Read ↗

Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.Semantic proximity Read ↗

Physiology and pathology of notch signalling system.Semantic proximity Read ↗

Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases.Semantic proximity Read ↗

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