Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential effects of the β-adrenoceptor blockers carvedilol and metoprolol on SQT1- and SQT2-mutant channels.

Journal of cardiovascular electrophysiology - 1 Oct 2013

Bodi Ilona, Franke Gerlind, Pantulu Naga Deepa, Wu Kezhong, Perez-Feliz Stefanie, Bode Christoph, Zehender Manfred, zur Hausen Axel, Brunner Michael, Odening Katja E

Abstract excerpt

BACKGROUND: N588K-KCNH2 and V307L-KCNQ1 mutations lead to a gain-of-function of IKr and IKs thus causing short-QT syndromes (SQT1, SQT2). Combined pharmacotherapies using K(+) -channel-blockers and β-blockers are effective in SQTS. Since β-blockers can block IKr and IKs , we aimed at determining...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenergic beta-Antagonists
Share to Carbazoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ERG1 Potassium Channel

Share to Ether-A-Go-Go Potassium Channels

Share to Heart Conduction System

Share to Metoprolol

Share to Potassium Channel Blockers

Share to Propanolamines

Source

Identifiers

PMID: 23718892
DOI: 10.1111/jce.12178

Genes

KCNH2
KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23718892-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential effects of the β-adrenoceptor blockers carvedilol and metoprolol on SQT1- and SQT2-mutant channels.PMID 23718892Read ↗

Overlapping LQT1 and LQT2 phenotype in a patient with long QT syndrome associated with loss-of-function variations in KCNQ1 and KCNH2.Semantic proximity Read ↗

Pharmacology of cardiac potassium channels.Semantic proximity Read ↗

Modulation of I(Kr) inactivation by mutation N588K in KCNH2: a link to arrhythmogenesis in short QT syndrome.Semantic proximity Read ↗

A molecular mechanism for adrenergic-induced long QT syndrome.Semantic proximity Read ↗

A novel mutation in the KCNH2 gene associated with short QT syndrome.Semantic proximity Read ↗

Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome.Semantic proximity Read ↗

Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias.Semantic proximity Read ↗

Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs.Semantic proximity Read ↗

Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation.Semantic proximity Read ↗

C-terminal long-QT type 1 R562S-Kv7.1 variant, the first variant in helix C impairing β-adrenergic response of the slow delayed rectifier K+ channel.Semantic proximity Read ↗

Enhanced effects of isoflurane on the long QT syndrome 1-associated A341V mutant.Semantic proximity Read ↗

A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.