Article
Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome.
Circulation - 24 Apr 2012
Barsheshet Alon, Goldenberg Ilan, O-Uchi Jin, Moss Arthur J, Jons Christian, Shimizu Wataru, Wilde Arthur A, McNitt Scott, Peterson Derick R, Zareba Wojciech, Robinson Jennifer L, Ackerman Michael J, Cypress Michael, Gray Daniel A, Hofman Nynke, Kanters Jorgen K, Kaufman Elizabeth S, Platonov Pyotr G, Qi Ming, Towbin Jeffrey A, Vincent G Michael, Lopes Coeli M
Abstract excerpt
BACKGROUND: β-Adrenergic stimulation is the main trigger for cardiac events in type 1 long-QT syndrome (LQT1). We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location. METHODS AND RESULTS: The study sample comprised 860 patients with genetically confirmed mutations in the KCNQ1 channel. Patients were...
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