Article
Comprehensive genetic and epigenetic characterization of Lynch-like syndrome patients.
International journal of cancer - 15 Aug 2025
Pirini Francesca, Calzari Luciano, Tedaldi Gianluca, Tebaldi Michela, Zampiga Valentina, Cangini Ilaria, Danesi Rita, Ravegnani Mila, Arcangeli Valentina, Passardi Alessandro, Petracci Elisabetta, Bravaccini Sara, Marisi Giorgia, Viel Alessandra, Barana Daniela, Pedroni Monica, Roncucci Luca, Calistri Daniele, Gentilini Davide
Abstract excerpt
Lynch-like syndrome (LLS) presents very similar clinicopathological characteristics to Lynch syndrome (LS) but the mechanism for cancer predisposition remains unknown. The present study aims to investigate the causal mechanism of LLS by a comprehensive genetic and epigenetic approach. Thirty-two LLS and 34 LS patients with colorectal cancer (CRC) fitting the Amsterdam and Bethesda criteria were included, along...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.