Article
Disrupted sleep and delayed recovery from chronic peripheral neuropathy are distinct phenotypes in a rat model of metabolic syndrome.
Anesthesiology - 1 Nov 2010
Muncey Aaron R, Saulles Adam R, Koch Lauren G, Britton Steven L, Baghdoyan Helen A, Lydic Ralph
Abstract excerpt
BACKGROUND: Sleep apnea, hypertension, atherosclerosis, and obesity are features of metabolic syndrome associated with decreased restorative sleep and increased pain. These traits are relevant for anesthesiology because they confer increased risks of a negative anesthetic outcome. This study tested the one-tailed hypothesis that rats bred for low intrinsic aerobic capacity have enhanced nociception and disordered...
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