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Article

Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.

The Journal of biological chemistry - 12 Jul 2013

Cui Guiying, Freeman Cody S, Knotts Taylor, Prince Chengyu Z, Kuang Christopher, McCarty Nael A

Abstract excerpt

Previous studies have identified two salt bridges in human CFTR chloride ion channels, Arg(352)-Asp(993) and Arg(347)-Asp(924), that are required for normal channel function. In the present study, we determined how the two salt bridges cooperate to maintain the open pore architecture of CFTR. Our...

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Identifiers

PMID: 23709221
DOI: 10.1074/jbc.M113.476226
PMCID: PMC3711338

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23709221-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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