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Article

The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating.

The Journal of physiology - 15 Apr 2006

Cui Liying, Aleksandrov Luba, Hou Yue-Xian, Gentzsch Martina, Chen Jey-Hsin, Riordan John R, Aleksandrov Andrei A

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel employing the ABC transporter structural motif. Deletion of a single residue (Phe508) in the first nucleotide-binding domain (NBD1), which occurs in most patients with cystic fibrosis, impairs both maturation and functio...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16484308
DOI: 10.1113/jphysiol.2005.099457
PMCID: PMC1779664

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16484308-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating.PMID 16484308Read ↗

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Can two wrongs make a right? F508del-CFTR ion channel rescue by second-site mutations in its transmembrane domains.Semantic proximity Read ↗

Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.Semantic proximity Read ↗

On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator.Semantic proximity Read ↗

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Modeling the Conformational Changes Underlying Channel Opening in CFTRSemantic proximity Read ↗

Conformational Changes Relevant to Channel Activity and Folding within the first Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance RegulatorSemantic proximity Read ↗

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