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Article

Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis.

Development (Cambridge, England) - 1 Feb 2008

Zhang Yongyou, Zhang Jue, Lin Yongshun, Lan Yongsheng, Lin Chunhong, Xuan Jim W, Shen Michael M, McKeehan Wallace L, Greenberg Norman M, Wang Fen

Abstract excerpt

The fibroblast growth factor (FGF) regulates a broad spectrum of biological activities by activation of transmembrane FGF receptor (FGFR) tyrosine kinases and their coupled intracellular signaling pathways. FGF receptor substrate 2alpha (FRS2alpha) is an FGFR interactive adaptor protein that links multiple signaling pathways to the activated FGFR kinase. We previously showed that FGFR2 in the prostate epithelium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18184727
DOI: 10.1242/dev.009910

Genes

FGFR2
FRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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