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Article

WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1α

1 Sept 2005

Abstract excerpt

Homing of lymphocytes to tissues is a biologically important multistep process that involves selectin-dependent rolling, integrin-dependent adhesion and chemokine-directed chemotaxis. The actin cytoskeleton plays a central role in lymphocyte adhesion and motility. Wiskott-Aldrich syndrome protein (WASP), the product of the gene mutated in Wiskott-Aldrich syndrome, and its partner, the Wiskott-Aldrich syndrome...

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Identifiers

PMID: 16141245
DOI: 10.1093/intimm/dxh310

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Related research

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WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1αPMID 16141245Read ↗

Requirement for a Complex of Wiskott-Aldrich Syndrome Protein (WASP) with WASP Interacting Protein in Podosome Formation in MacrophagesSemantic proximity Read ↗

Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B CellsSemantic proximity Read ↗

A Complex of Wiskott-Aldrich Syndrome Protein with Mammalian Verprolins Plays an Important Role in Monocyte ChemotaxisSemantic proximity Read ↗

Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activationSemantic proximity Read ↗

WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cellsSemantic proximity Read ↗

The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP)Semantic proximity Read ↗

WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo.Semantic proximity Read ↗

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeletonSemantic proximity Read ↗

WIP is critical for T cell responsiveness to IL-2Semantic proximity Read ↗

Wiskott–Aldrich syndrome protein (WASP) and N-WASP are critical for T cell developmentSemantic proximity Read ↗

WIP null mice display a progressive immunological disorder that resembles Wiskott–Aldrich syndromeSemantic proximity Read ↗

WASP and WIP regulate podosomes in migrating leukocytesSemantic proximity Read ↗

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