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Article

Primary hepatocellular neoplasms in a MODY3 family with a novel HNF1A germline mutation

23 May 2013

Abstract excerpt

Maturity onset diabetes of the young type 3 (MODY3) and hepatocellular adenomas (HCAs) are associated with mutations in the HNF1A gene. HNF1A codes for the transcription factor HNF1α, which interacts with DNA as a homodimer or a heterodimer with HNF1β, to regulate multiple cellular functions including glucidic metabolism, lipidic transport, and detoxication. We report three members of one family with a novel...

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PMID: 23707370
DOI: 10.1016/j.jhep.2013.05.024

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