Article
Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3).
Human molecular genetics - 1 Apr 1997
Vaxillaire M, Rouard M, Yamagata K, Oda N, Kaisaki P J, Boriraj V V, Chevre J C, Boccio V, Cox R D, Lathrop G M, Dussoix P, Philippe J, Timsit J, Charpentier G, Velho G, Bell G I, Froguel P
Abstract excerpt
Maturity-onset diabetes of the young (MODY) is a genetically heterogeneous subtype of non-insulin-dependent diabetes mellitus (NIDDM) characterised by early onset, autosomal dominant inheritance and a primary defect in insulin secretion. Recent studies have shown that mutations in the two functionally related transcription factors, hepatocyte nuclear factor 4 alpha (HNF-4alpha) and hepatocyte nuclear factor 1...
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