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Article

Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage.

Diabetes - 1 Jul 2010

Jeannot Emmanuelle, Mellottee Lucille, Bioulac-Sage Paulette, Balabaud Charles, Scoazec Jean-Yves, Tran Van Nhieu Jeanne, Bacq Yannick, Michalak Sophie, Buob David, Laurent-Puig Pierre, Rusyn Ivan, Zucman-Rossi Jessica

Abstract excerpt

OBJECTIVE: Maturity onset diabetes of the young type 3 (MODY3) is a consequence of heterozygous germline mutation in HNF1A. A subtype of hepatocellular adenoma (HCA) is also caused by biallelic somatic HNF1A mutations (H-HCA), and rare HCA may be related to MODY3. To better understand a relations...

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Share to Adenoma, Liver Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20393147
DOI: 10.2337/db09-1819
PMCID: PMC2889786

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20393147-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage.PMID 20393147Read ↗

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Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young.Semantic proximity Read ↗

Expanded Clinical Spectrum in Hepatocyte Nuclear Factor 1B-Maturity-Onset Diabetes of the YoungSemantic proximity Read ↗

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