Article
Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY).
Clinical and investigative medicine. Medecine clinique et experimentale - 1 Jun 2004
McKinney James L, Cao Henian, Robinson John F, Metzger Daniel L, Cummings Elizabeth, Riddell D Christie, Sanderson Susan R, Pacaud Daniele, Ho Josephine, Hegele Robert A
Abstract excerpt
PURPOSE: Maturity-onset diabetes of the young (MODY) is a subtype of type 2 diabetes characterized by autosomal-dominant inheritance and early onset. The pathophysiology of MODY is primarily defective insulin secretion resulting from mutations in at least 6 different genes. Most affected patients harbour mutations in either GCK (encoding glucokinase, also called MODY2) and HNF1A (encoding hepatic nuclear...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.