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Article

Primary hepatocellular adenoma due to biallelic HNF1A mutations and its co-occurrence with MODY 3: case-report and review of the literature.

Endocrine - 1 Mar 2020

Fu Junling, Wang Tong, Zhai Xiao, Xiao Xinhua

Abstract excerpt

PURPOSE: Maturity-onset diabetes of the young type 3 (MODY 3) is a consequence of heterozygous germline mutations in HNF1A, and a subtype of hepatocellular adenoma (HCA) is caused by biallelic somatic HNF1A mutations; rare HCA may be related to MODY 3. This study aimed to investigate the cosegregation of HNF1A mutations with diabetes and HCA in two families. METHODS: Two patients suffering from HCA and diabetes...

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Share to Adenoma, Liver Cell
Share to Cancer-related gene regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Diabetes Mellitus, Type 2

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Liver Neoplasms

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Share to Pancreatic function and diabetes

Source

Open in PubMed Open full text

Identifiers

PMID: 31754975
DOI: 10.1007/s12020-019-02138-x
PMCID: PMC7054351

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