Article
Inactive or moderately active human promoters are enriched for inter-individual epialleles.
Genome biology - 25 May 2013
Gemma Carolina, Ramagopalan Sreeram V, Down Thomas A, Beyan Huriya, Hawa Mohammed I, Holland Michelle L, Hurd Paul J, Giovannoni Gavin, Leslie R David, Ebers George C, Rakyan Vardhman K
Abstract excerpt
BACKGROUND: Inter-individual epigenetic variation, due to genetic, environmental or random influences, is observed in many eukaryotic species. In mammals, however, the molecular nature of epiallelic variation has been poorly defined, partly due to the restricted focus on DNA methylation. Here we report the first genome-scale investigation of mammalian epialleles that integrates genomic, methylomic, transcriptomic...
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